Ep. 4 – Owner’s Manual Part One

Antoine: [00:00:00] I watched her colors just go to white. To her lips are blue and purple. 

Jesse: Antoine Sartin is sitting in a hospital room with his daughter, Callie. 

Antoine: We always got a beg on standby. 

Jesse: How many times, if you were to guess, has Kelly been in and outta the hospital? 

Antoine: Oh man. At one point in time, I could tell you. I mean just in 2024, she was in and outta hospital. I mean, if it wasn’t every three weeks, it was once a month.

Faith: When something happens that often, it stops feeling like an emergency. It becomes life. 

Antoine: When they start to know you face to face and know you are the, you know, your first name basis, or who your child is, that’s quite a bit of visits to the hospital. 

Jesse: Yeah. Yeah. That song “Where Everybody Knows Your Name” should [00:01:00] not apply to the hospital.

Antoine: Yes. Not at all. 

Faith: Antoine is watching her chest rise and fall. 

Antoine: You know, all these different machines, all these different noises going on, and it’s like she couldn’t even breathe, so it was like she was just gasping for air. 

Jesse: Antoine needs a moment, and so he steps outside the hospital room. 

Antoine: And I had a talk with God and I said, if this is you calling for her, just, you know, gimme the strength. I’ve never told nobody this. I said, gimme the strength. That’s all I asked. If you want her, give me the strength to give her to you. And, uh peacefully. 

Faith: He said he tries to keep from feeling angry, but every now and then it slips through. 

Francis Collins: I wish he was me going through it and not my child. ’cause I don’t wanna see, you don’t wanna see your child suffering. You would take that pain for them. [00:02:00] And that’s, that’s, that’s the times that I’m angry when I wish I could just, I wish it could be me going through it and not her.

Jesse: In that hallway, there’s nothing he can do. 

Faith: No fix, no control. Just wait. 

Jesse: And for most of human history, this is how the story of disease goes. 

Faith: You wait, you hope, and you don’t know why it’s happening. 

Jesse: But what if the first step to healing the body is understanding it. Tonight on Wonderology, we’re looking at how one mysterious illness changed the way medicine sees the body.

Faith: The illness Cali lives with was once a complete mystery, doctors could see the pain. They just couldn’t explain. 

Jesse: Until one patient in another hospital more than a century ago, forced medicine to look closer and what they discovered didn’t just name a disease. It changed what medicine thought it was looking [00:03:00] at.

Faith: We’re asking the question, what if our bodies came with operating instructions and we could finally read them. 

Jesse: I’m Jesse Eubanks, a storyteller and journalist. 

Faith: I’m Faith 

Stults, a science educator, 

Jesse: so let’s get curious. S.

Today’s story starts in 1904 Chicago. A young man steps off a train. He’s 20 years old, and his name is Walter Noel. He’s come from Granada across an ocean to study dentistry. 

Faith: Walter comes from a wealthy family. He’s ambitious, educated. This move is supposed to open his life up. 

Jesse: But, something is wrong. He’s fatigued, his joints ache.

Breathing is getting harder and it doesn’t let up. 

Faith: At first, he tries to push through it. Keeps his routines. Assumes it will pass. 

Jesse: But [00:04:00] after more than a month. It doesn’t. So he goes to the doctor an intern draws his blood. Early 1900s, medicine is starting to trust the lab. They stain the slide, place it under a microscope, and instead of assuming what his blood looks like, they take a look.

Faith: You probably know what blood cells are supposed to look like. They’re round little discs. Smooth, flexible. They look like full moons. 

Jesse: But Walters don’t. Under the microscope, his cells are bent, curved, sharp. They don’t look like full moons. They look like crescent moons, like sickles.

Faith: And that shape matters. Red blood cells are supposed to be soft. They’re built to squeeze through vessels thinner than a hair. 

Jesse: And Walter cells don’t look soft. They look like they could snag, like they could jam up traffic. 

Faith: And when blood can’t move, oxygen can’t either. [00:05:00]

Jesse: And this explains his exhaustion, his shortness of breath. Doctors can see his pain, they just don’t know what’s causing it.

A case report publishes in 1910 where a doctor describes Walter’s unusual blood in the years that follow other physicians began reporting the same thing. 

Faith: Different hospitals, same symptoms, same misshapen cells. 

Jesse: So the disease is named for what it looks like sickle cell anemia. For decades, little changes.

Treatment remains limited. There is no cure. 

Faith: Meanwhile, other diseases command national attention. 

News Clip: There was a statistical survey to determine who needed the polio shots. 

Faith: Diseases like polio, tuberculosis, and syphilis. They mobilized public health campaigns, philanthropy, research institutes. 

Jesse: Sickle cell [00:06:00] does not.

In the United States, most sickle cell patients are black. And by the 1920s, some medical journals describe it as a “Negro disease”. In 1916, Walter dies. He’s just 32. 

Faith: How does he die? Pneumonia. Days earlier, he had overexerted himself walking a long distance and bathing in the same day. And for someone with sickle cell, that kind of strain can trigger a crisis. A body already fragile can tip and an ordinary infection becomes fatal. 

Jesse: Decades pass and people continue to live in constant pain. But by the 1940s, scientists are beginning to suspect that something chemical is going on inside us. A molecule called DNA enters the conversation and new tools, let researchers look past the cell itself, down to the molecules inside it.[00:07:00]

And so they turn back to sickle cell. 

Faith: And what they find changes everything. The problem isn’t the whole blood cell. It’s the hemoglobin. Tiny change in that protein, a single molecular swap, and the cells stiffen, they bend, they sickle. 

Jesse: For the first time, a human disease is traced to a change in a single molecule, a molecular typo rooted in the DNA itself.

Faith: Years later, they realized the mutation is actually ancient, a mutation to protect against malaria if you inherit one copy, but devastating if you inherit two. That survival advantage allowed the mutation to become common in much of Sub-Saharan Africa. This is why sickle cell disease disproportionately affects people whose ancestry traces to those regions.

Jesse: Tracing sickle cell to a single molecule raises an obvious [00:08:00] question. If you can link one disease to one gene, how many others are written into our DNA decades later, a young physician comes of age asking that question. 

Francis Collins: I ended up at the University of Michigan as a researcher teaching medical students, taking care of patients.

Jesse: This is Francis Collins. In the late eighties, he’s working in a hospital, seeing patients every day, families who come back again and again. 

Francis Collins: Trying to find the cause of cystic fibrosis. I wanted the diseases that I saw and grieved over because it was so incredibly difficult for individuals and families to deal with.

Faith: Doctors can manage pain, treat infections, ease breathing, but they don’t know what’s underneath. 

Francis Collins: And nobody knew anything really about what the problem was or how to treat it other than the sort of symptom treatment. 

Jesse: So Francis and his team keep [00:09:00] digging. And in 1989, they finally identify the gene mutation that causes cystic fibrosis.

Francis Collins: After five years of incredibly difficult sifting through bits of chromosomes, uh, we found the answer that cystic fibrosis was caused by just three missing letters in one gene on chromosome seven. 

Jesse: Three missing letters out of 3 billion. A needle in a genetic haystack. 

Francis Collins: But that was really hard to get that answer for just one disorder. 

Faith: If it took that much work to answer one question, what about all the others?

Francis Collins: And it was pretty clear if you really wanted to do this for the thousands of conditions that affect us, or you know, something’s misspelled somewhere in DNA, you need to have a reference copy. 

Faith: A copy of the long chain of human DNA without any mutations, a master key. 

Jesse: [00:10:00] A few years later, Francis starts hearing about an idea.

It’s big and expensive. The idea? Mapping the entire human genome. 

Francis Collins: And when the human genome project was being proposed, and I was a fan of it, uh, most scientists didn’t really support it. They thought, this is never gonna work. This is too hard. 

Faith: And they also had ideas about the team behind it. 

Francis Collins: And the most offensive one was people who said, well, only mediocre scientists would wanna work on it because it’s gonna be so boring. 

Jesse: Francis applied for a small grant anyway.

Francis Collins: I wanted to be part of it so when the first announcement for some funds to get started, I wrote an application and I got one of those first six grants to get the project started in a modest scale. 

Jesse: Then, one day, his phone rings. It’s the director of the National Institutes of Health. They want him to apply to lead the Human Genome Project. 

Francis Collins: I want you to [00:11:00] apply for this job ’cause I think you’re the one to step in and take on what was, at that point, sort of the baby genome project in the crib and see if you can help it grow up and actually accomplish something.

That was a big, frightening idea. Most of my colleagues were saying, this isn’t gonna work. Uh, it’s a fool’s errand. Why would you possibly want to put yourself at risk by taking on a project that you will forevermore be remembered as the leader of a failure? 

Jesse: Francis says, no. 

Francis Collins: You had to become a federal employee. Something my mother told me never to do. 

Jesse: So they ask again and he says no again. 

Francis Collins: But after a while, I, I had to realize that I was about to sort of walk away from what if it worked was probably the most significant scientific project of our time. Um, yeah, going to the moon was a big one. Uh, splitting the atom was a [00:12:00] big one.

But this is about us. This is about our very essence. Our own instruction book. You only are gonna do that one time if it succeeds. And I was gonna say, well, it’s not convenient right now? I couldn’t say it. So I said, yes. 

Jesse: When we come back, Francis tries to put a team together to embark on a new frontier for humanity: mapping the billions of letters of our DNA code from start to finish. 

Faith: And it turns out this effort is going to be hard for far more reasons than just science. 

Jesse: We’ll be right back.

Welcome back to Wonderology, Jesse Eubanks 

Faith: Faith Stults. 

Jesse: Before the break, Francis Collins said yes to leading the human genome project. 

Faith: 3 billion letters in the human, DNA billions of dollars. If it fails, he will be remembered as the scientist [00:13:00]who bet the future of biWonderWonderWonderology on a fantasy. 

Jesse : But if it succeeds, we’ll read our own instruction manual for the first time in human history.

News Clip: Our next segment deals with human genetics and a huge research project to locate and identify all the genes in the human cell. While genes determine appearance and even state of mind, they also carry illness or the predisposition to it. Scientists are developing ways to identify disease carrying genes and how best to deal with them. 

Jesse: So what does mapping the human genome even look like? If you wanna know what’s broken in our genetics, you first have to know what normal looks like. 

Francis Collins: You need to have a reference copy. You need to be able to start somewhere and say, okay, what’s different here? 

Faith: That instruction book is written in a code.

Francis Collins: The language has only four letters in it’s alphabet. They’re actually [00:14:00] chemical bases, abbreviated ACG and T. 

Faith: One continuous chain of ever-changing patterns. Shift the pattern and the body builds something different. 

Francis Collins: Having 3 billion of those letters in a particular order is enough for a single cell to develop this incredibly elegant, beautiful, amazing complexity of a human being.

Jesse: If that number is hard to picture: 

Francis Collins: if you printed out the human genome, those 3 billion letters on, on regular paper at a reasonable font size, and you piled the pages up on top of each other, uh, that would be about the height of the Washington Monument. 

Jesse: That stack of paper is inside every cell of your body. 

Francis Collins: And every time the cell divides, you have to copy the whole thing, and you need to get it right.

Jesse: This is what they’re trying to read. It’s [00:15:00] 1993 when Francis steps in as the new leader. 

Francis Collins: The technWonderWonderWonderology we had when it started in 1990 was so rudimentary. You might be able to read a hundred letters on a good day, and we had to go to 3 billion. Uh, no way is that gonna happen. 

Faith: 100 letters on a good day. And by the time France arrives, the technology has not improved much. 

Jesse: Day after day.

Tiny fragments. With no sense yet of where any of them belong. 

Faith: Imagine you’ve been handed a closeup photo of a white highway stripe. Just the paint and asphalt and someone tells you this was taken somewhere on I 95, but I 95 runs from Florida to Maine. That stripe could be anywhere along the way. You just don’t know which mile. 

Jesse: They know what they’re looking at. They just don’t know how it fits together. And while the genome seems [00:16:00] scattered in fragments, so was Francis’ life. 

Francis Collins: I was single. Marriage had broken up. My two daughters, uh, were at that point of being in college and medical school. So it was just me and uh, yeah, that made it slightly less complicated, but also pretty lonely.

Faith: 3 billion letters, a skeptical scientific community, and no one at home. 

Jesse: Francis also knows that this isn’t a normal science project. He’s gonna need a lot more than just scientists. 

Francis Collins: Some of them needed to be engineers and some of them need to be computer experts. And, and some of them needed to be sort of business-minded people about how do you build kind of a factory to actually do the work, not just write it down on a piece of paper.

Faith: This kind of team is unusual at the time. Science mostly lives in silos. Biology over here, computers over there. Now, they’re being asked to work together. [00:17:00]

Jesse: And on top of that, Francis is asking people to leave jobs they like. Labs that work. Reputations they’ve already earned. 

Faith: And there’s no safety to offer, no clear career upside, no guaranteed success.

Francis Collins: And it really was the whole idea of the historic nature of this. That was my best recruiting tool. 

Jesse: Little by little, the team comes together.

At first, the plan feels obvious. If reading DNA is slow, a single lab trying to run at super speed isn’t going to work. They needed more labs. 

Francis Collins: And I was probably still at that point thinking like an academic. Okay, maybe if we fund 50 of these centers that can all do 2% uh, we’ll get there. 

Jesse: So the project spreads across the country, across the world.

[00:18:00] Genome centers multiply. 

Francis Collins: The project also adopts an unusual rule. We were putting all the data up on the internet every 24 hours. All of this data is gonna be immediately available to everybody. 

Jesse: This idea was not shared by everyone else. 

Francis Collins: There was a lot of debate, 

Jesse: but 

Francis Collins: ultimately it was a unanimous decision.

In retrospect, probably few of the people in the room had the authority to do what they had just agreed to, and we just sold it, but it was the right thing to do. 

Faith: There was another reason too. 

Francis Collins: We could not afford to be seen, to be slow and inefficient. 

Jesse: But posting soon reveals something. 

Faith: Some labs are moving fast, others aren’t. 

Francis Collins: You could see that of those centers that were trying to do this, there were some that were doing amazing things. They got it. They knew how to scale, and there were others that were just kind of doing what they’d been doing., 

Jesse: Doing good [00:19:00] science is not enough. 

Francis Collins: They just didn’t quite have the mindset, uh, of what it took to become almost like a factory.

Faith: And that means, Francis has to make a call he never expected to make.

Francis Collins: And it was my job to sort of weed the garden and that was painful. 

Faith: These aren’t people who simply failed a performance review. They’re colleagues. 

Francis Collins: Many of them have dropped everything else in order to do this

Jesse: which means the phone calls aren’t abstract, they’re personal.

Francis Collins: It made you ache when you had to say to somebody who’d really, oh put what they thought was their best effort into this, I’m sorry, we’re gonna have to basically cut this off here. 

Faith: Even now, years later, that part hasn’t gone away. 

Francis Collins: When I think of those folks or when I run into the meeting, I still feel this sadness, uh, that that’s the way it had to be.

Jesse: At the beginning, there were about 20 genome centers. [00:20:00]

Francis Collins: And by the time we got done, effectively, there were five. 

Jesse: Five teams, five leaders. People who are used to running their own kingdoms. And some of them, 

Francis Collins: they did not have small egos 

Faith: and they don’t agree on how to finish the job. 

Francis Collins: There was still a lot of disagreements about the strategy.

Faith: Imagine someone hands you the pages of an instruction manual, but they’ve been torn into millions of thin strips. You don’t have page numbers. You don’t even know where the first sentence begins, and there are two different proposals on how to repair it. 

Francis Collins: It’s the Clone by clone group 

Faith: One side says, let’s rebuild it page by page.

Anchor one whole section then move to the next: slow, careful. That’s clone by clone, 

Francis Collins: and there’s a shotgun group. 

Faith: The other side says, forget pages. Read every strip at once. Feed them into a [00:21:00] computer and let the machine piece it all together. That’s shotgun. 

Francis Collins: And they didn’t necessarily love each other. 

Faith: Both get you the same instruction manual.

One is slow and orderly. The other is fast and chaotic. 

Francis Collins: Fights would break out. Not physical fights, but intellectual fights about strategy. And sometimes they got pretty animated and it was my job sometimes to after one of those, to take somebody to the woodshed and say, “you really can’t talk to your colleague that way.”

Jesse: But before they can settle the argument, someone else enters the race. 

Faith: They’re not here to join the effort. They’re here to replace it and they want Francis and his team out of their way. 

Jesse: When we come back a fight over who gets to own the code of life. Stay with us.

Wonderology, [00:22:00] Jesse. 

Faith: Faith. Before the break, the Human Genome Project has been underway for years. 3 billion letters, slow progress, fragile technology, and scientists who can’t agree on how to finish the job. 

Jesse: But before those debates can settle, a new threat appears and suddenly the question changes, not just can we map the genome, but if we succeed, who owns it?

A private, well-funded company enters the race. 

Francis Collins: A commercial version of this emerged, uh, that was being put forward by a for-profit company.

Jesse: Celera Genomics. 

News Clip: The leading genetic scientist Dr. J Craig Venter and a private biotechnology company are teaming up to decode the entire human genome within three years. Years ahead of a [00:23:00] federally funded effort called the Human Genome Project.

Jesse: They aren’t saying the genome project can’t be done. They’re saying the government shouldn’t be the ones to do it, and they’re saying they can do it in just three years. 

Francis Collins: Basically arguing that the government efforts should just be shut down because they can do it faster, better, if not cheaper. 

Jesse: And they don’t whisper it.

This is Celera, president Craig Venter. 

Craig Venter: I think the scientists sort of claimed that they were gonna do this public program. almost started to believe it was their birthright to get all this money and take the next several decades to do this project. 

Faith: And in Washington, faster, better, cheaper? That argument lands.

Francis Collins: There was a bit of an existential threat there that the commercial entity might convince the Congress who was funding all this that the government part could basically be phased out. 

Jesse: If Congress pulls funding, [00:24:00] the public genome dies. Years of work gone.

Celera’s promise to map the genome faster and cheaper wasn’t the only difference. 

Francis Collins: They were gonna make this into a commodity. You wouldn’t have access to the information unless you paid for it. 

Jesse: Now, with a government funded effort and a private funded effort, both happening at the same time, pressures mount from the outside. Politicians, international labs, investors, all urging some kind of deal, but neither side backs down.

Celera refuses to promise open access. The public project refuses to privatize the genome. 

Francis Collins: That’s our shared inheritance. Our own genome is gonna be owned by somebody? That’s just wrong. 

News Clip: It’s not just about science, but also about the race for vast sums of money.

Are you gonna win? We’re not gonna lose. 

Faith: Now, this isn’t just a race, it’s a fight over [00:25:00] ownership. One vision treats the genome like property. Something you patent, something you sell. The other treats it like inheritance. Something shared, something received. And the difference between those two ideas is who gets to read the book.

Jesse: Early 1999, Houston. With the mounting threat of Celera Genomics, the five centers rallied together to decide what happens next.

Faith: Different team members argue for one of the two approaches. 

Jesse: But Francis throws a curve ball. 

Francis Collins: I’d thought a lot about this. I’d done a lot of mapping and modeling. 

Jesse: He proposes a third option. 

Francis Collins: I became convinced the right answer was a hybrid. 

Faith: Lay down the big structure first so you know where things belong.

Then, flood it with fragments and let computer modeling do the rest. 

Francis Collins: People were not expecting it and we’re not initially all that receptive. And there was a lot of pushback and then some refinements of what [00:26:00] I had put forward to make it better. And by the end of the day, that was the strategy. 

Jesse: If this works, they might finish the genome years faster. But if it doesn’t, they’ll only fail faster.

After Houston and after years of building the tools and arguing about the plan, they’re now at a threshold. 

Francis Collins: Everything up until that point was working on simpler organisms and building the technology, uh, to be good enough to tackle 3 billion. And then we were ready to start scaling up. 

Faith: The conveyor belt is suddenly on full speed. 

Francis Collins: And once you had the, the bits and pieces of DNA information and have this massive computer effort, uh, to actually assemble, letting them know you got it right and didn’t misconnect things. 

Jesse: And over the next year, a map starts coming into focus.

Faith: This is working. 

Jesse: By early 2000, [00:27:00] both the public project and Celera are claiming that they’re nearing draft completion. With the potential of an announcement in the near future, President Clinton steps in and encourages a compromise. 

Francis Collins: Having the chance also to negotiate with the company who I think at that point recognized the public project really was succeeding. 

Faith: Both groups will publish separate papers in separate major publications.

Both will describe their own drafts and 

Francis Collins: that it would be better if we had an announcement of sort of joint success as opposed to somebody won and somebody lost. 

Jesse: An agreement is reached. 

News Clip: Scientists are expected to announce on Monday that they have mapped the entire human gene structure. 

Jesse: But as the White House announcement approaches, 

Francis Collins: my sister-in-law.

who was this incredibly creative Marinette artist died of cancer, breast cancer, and I gave [00:28:00] the eulogy for her on a Saturday in my hometown of Stanton. I had high hopes that the study of the genome would give us insights into cancer so that so many people wouldn’t have to die. And yet, we were too late for her.

Faith: Two days after the funeral, the morning of the announcement arrives. 

Jesse: Francis walks alongside President Clinton to a room full of reporters. 

News Clip: We are here to celebrate the completion of the first survey of the entire human genome. Without a doubt, this is the most important, most wondrous map ever produced by humankind. More than a thousand researchers across six nations have revealed nearly all 3 billion letters of our miraculous genetic code.

Today’s announcement represents more than [00:29:00] just an epic making triumph of science and reason. After all, when Galileo discovered he could use the tools of mathematics and mechanics, he felt in the words of one imminent researcher, that he had learned the language in which God created the universe. Today, we are learning the language in which God created life.

We are gaining evermore awe for the complexity, the beauty, the wonder of God’s most divine and sacred gift. And now, I’d like to invite Dr. Francis Collins to the lectern.

Francis Collins: And uh, because I’d been at her funeral, I was sort of distracted and it wasn’t until five o’clock that Monday morning AM that I started to write down what I was gonna say , at the event in the East Room. And I was so much feeling like this is a moment to not just talk about what science has done, but what God has done, [00:30:00] uh, with the creation to make it possible for life like ours to exist.

It is humbling for me and awe inspiring to realize that we have caught the first glimpse of our own instruction book previously known only to God. What a profound responsibility it is to do this work. 

Jesse: Even now, Francis still seems amazed. 

Francis Collins: We really did this, but, wait a minute, before we ever got to it, God really did this and we’ve been given this gift, uh, in a form of worship really, of being able to see this elegant, beautiful, mysterious creation for the first time.

Jesse: For the first time in history, we can read the code of life.[00:31:00]

But reading was never the end. 

Faith: It was the doorway. 

Jesse: If mapping the genome was the end of the beginning. Then the next step wasn’t just reading, it was picking up a red pen. 

Faith: More than 25 years later, we haven’t just learned to read our instructions. We’ve learned how to revise them. To reach into the code itself and change it.

Jesse: For most of human history, parents like Antoine have sat beside a hospital bed with nothing but hope. Waiting. But what if waiting isn’t the only option anymore? What could it mean to correct the typo that’s hurting his daughter? 

Faith: Because once you can edit the code of life, you can relieve suffering in ways that once felt impossible. But you’re also moving from discovery into authorship. 

Jesse: How has the power to rewrite our own instructions changed us? And who do we [00:32:00] become if our power outpaces our wisdom? That’s next time. Part two of Owner’s Manual.

Faith: Your journey into wonder doesn’t have to end here. If today’s episode sparks something in you, we’ve got more. 

Jesse: Check out “Science With Faith”, our exclusive after show where Faith unpacks the deeper layers of science and faith behind each episode.

Faith: Or dive into everything from nothing. Our special mini series hosted by Jesse Exploring Evolution and Christian faith.

Jesse: Both our free and waiting for you at wonderologyshow.com.

That’s wonderologyshow.com. Special thanks to Francis Collins and Antoine Sartin. Additional thanks to Matt Stevens. Wonderology is a production of Christianity Today in partnership with Bio Logos. 

Faith: It’s hosted by Jesse Eubanks and Faith Stults. Today’s episode was written by Jesse Eubanks, science fact checking and guidance from Faith Stults, Jim Stump and Colin Hoogerworth.

It was produced by Jesse Eubanks. [00:33:00] Our associate producer is McKenzie Hill. Music by Jesse Eubanks. 

Jesse: Editing by Rachel Akers. Post-production by Wind Hill Studios, with sound design, scoring, mixing, and additional story editing by Mark Henry Phillips. Additional music by Mark Henry Phillips and Blue Dot Sessions.

Faith: Eric Petrik is the executive producer of CT Media podcasts. Matt Stevens is our senior producer. 

Jesse: Wonderology is generously funded by the John Templeton Foundation. Explore the profound questions of life that inspire awe and wonder by visiting templeton.org. 

Faith: If you enjoyed this episode, send it to a friend and leave us a rating and review to help more people find the show.

Jesse: God invites us to experience the awe of all that he’s made, but the known. And the not yet known, so let’s get curious.